I am not sure about your region.
When I was normal regional I was home most weekends. It may or may not be the full weekend though. Depending on the freight and what they have you bring home.
Regional pay is not as good as system pay. And system drivers are out 2-3 weekends per month.
But they get .04 cpm more for that. And if in the Northeast green mile area, they get another .04 for that.
Some people like the way they run, and others hate it.
As I have said on here many times. Not allot of long loads. They are short to medium haul.
Allot of drop and hook, and since we went to e-logs in Feb, allot more swapping of loads.
Plan to pickup and deliver at least 1 load per day.
Allot of my loads I will deliver in the AM. Pick up in the AM at next shipper. And deliver that load the next morning.
Most loads do not have allot of extra time on them.
If they do, then the load goes to a yard if possible, to get delivered later.

If you have a good dispatcher you will get ok miles for the pay. You will not see 3000 mile weeks often, or ever.
2200-2500 is good. And when you are getting paid a good bit more than at most other company's, it evens out.
So you will make about the same money, for less work. You will probably not make more money at Heartland than at other company's. But you will not work as much either.

I have never worked for Knight or Schneider.
The only thing I can say is that those are both training company's. Heartland is not. They only hire experianced drivers.
They will not lead you by the hand, and they expect you to know what you are doing from day 1.