Both have their pros and cons. And really, it's all going to depend on the requirements of the load.

Night: Pros are fewer cars, not as hard to get a parking spot when you are pulling in as or after others are pulling out. Cons: in bad weather it can be very difficult to see the road, after last call the drunks are all over the road, sleepies between 4am and 6am, harder to see road signs.

Day: Pros- you can see where you are going in weather and when looking for road signs. Not as much of the sleepies. Cons - irritated and impatient drivers, especially in larger towns and cities. Finding a parking spot can get tricky.

There are more, but that's off the cuff.

I like night time running. But I'm old school. We ran alot at night to help the truck. Everything stays cooler. Less traffic. The trucks ran better at night with the cooler air.

night time better,not much traffic.

Schedule will vary with the load, but I drive at night and in the morning lots, and going into Chicago, I will vary the route taken to reduce driving in the city if arrival will be delayed.

I actually drive any time of the day or night as required. You can run into impaired drivers and wildlife almost any time, but an accident during the day on a big road near or in a city puts a serious brake on traveling.

Nights. Calmer 4 wheelers and 18 wheelers. Traffic is less hectic USUALY but not always. Fueling much easier. The CB isn't blabin all night. But you do have to be even more alert -- construction, signs less obvious, deer jumping out at ya, bad weather is even worse when your visibility is already decreased, drunks, and yeah-- the sinking spell for me is usually around 3 to 5 am. And you'll get RAMP ENVY cuz you'll want to pull over for "just a quickie" but they are usualy all full.

alot of appointment times are during the day.

there can be MORE construction at night than during the daytime.

i run nights, but by golly, so do the construction companies..!!!

hazards of running nights were already said. but i will add yet another, construction detours. at anytime, the roads can be shut down, i know from my run, Boston can be a biotch to navigate when the streets are open at night...

but when they close off one of MY streets..??

well let's just say, my 53 foot trailer and i manage to avoid taking down street light poles and parked cars..!!!

but all in all. i still prefer night time driving.