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A magnesium red cell test (also called RBC magnesium test) measures the amount of magnesium inside your red blood cells, rather than in your blood serum or plasma.
Why is this test done?
Magnesium in the red blood cells (RBCs) gives a better picture of your long-term magnesium status, since:
Serum magnesium levels can appear normal even if you have a deficiency.
Only ~1% of your body's magnesium is found in the blood serum.
Magnesium is mostly stored inside cells, especially in bone and muscle.
The RBC magnesium test helps detect chronic or intracellular magnesium deficiencies that may not show up in standard blood tests.
How is it performed?
A blood sample is taken.
Red blood cells are separated and analyzed for magnesium content.
Usually reported in milliequivalents per liter (mEq/L) or milligrams per deciliter (mg/dL).
Why might your doctor order this test?
To evaluate:
Chronic fatigue
Muscle cramps or spasms
Arrhythmias (irregular heartbeat)
Migraines
Fibromyalgia or chronic pain
Poor response to oral magnesium supplements
Magnesium loss due to certain medications (e.g., diuretics, PPIs)