Best route

72 down to 78 in Holly Springs......then 78 all the way to Tupelo then Birmingham........72 is good, 78 is great....divided 4 lane.....till you get to BHM then it kinda blows the last mile or so
Then 65 to Montgomery, then 231 all the way to 10. Then 10 across the panhandle to 75.

You're probably gonna want to park about the time you get to 10, just go east. About 5 miles is a Loves and about 10 miles is a TA.....both are good sized. If you have to fuel at Pilot, there's one on the other side of the interstate from the TA, just no room to park (maybe 25 trucks).

 

Agreed, about the best I would do too!!! Safe trip!!

 

Dipschitt, just about 10 miles before BMH, do you mean take 78 all the way or take OLD 78 (at exit 85) those last 10-12 miles?
I see some indications via Google maps that newer 78 is posted "No trucks and local traffic only", due to the construction completion.
Not sure how "updated" this info is. You may know first hand and better.

 

Gotta follow the truck route, last time I went through it was about 10 miles before BMH (85) then bear right by Pilot to 20/59 or stay left to 65. If you decide to bear right take 20 east to 65 south.

 

I use several features combined, on Google Maps.
Start with the Map layout, then I also go to Satellite View, where you can also zoom in pretty close.
As a final step many times, I go Street View.

As an example, here is a screenshot of Exit 85, showing a sign "Local Traffic Only - No Trucks" on the continuation part of newer Hwy 78.
You always need to verify things seen in Street View, as sometimes the camera's view can be fairly recent,
or it may be from, say,, a year ago and subject to have been changed.

 

It has been a rather long time since I've been down there, so it may have changed by now. If you continued on it was a local route only because the construction to connect the freeway grade US-78 into I-65 in Birmingham had not been completed yet.

According to the US-78 entry on Wikipedia, it is not completed to I-65 yet.