What are cdl's

Wouldn't that cover the 4 wheelers...we as CDL holders are special so we fall out of that grouping....right?

 

You forgot Colorado and Connecticut...

 

I try to...but people like you keep reminding me they still exist!

 

Only cause people like you keep reminding us the wrong coast exists

 

That's LEFT COAST...please!

 

Ya'll are just bad....ya done took the man's thread and highjacked it....*sigh* what in the world are they gonna do with ya'll...LOL

 

Cornelia de Lange Syndrome
​

Cornelia de Lange Syndrome aka CdLS is a genetic disorder that can lead to severe developmental anomalies. It affects both the physical and intellectual development of a child. Exact incidence is unknown, but is estimated at 1 in 10,000 to 30,000[1]

Causes
The vast majority of cases are due to spontaneous mutations.[citation needed]
It can be associated with mutations affecting the cohesin complex.[2]
Multiple genes have been associated with the condition:

A gene responsible for CdLS on Chromosome 5 was discovered in 2004 jointly by researchers at the Children’s Hospital of Philadelphia, USA [3] and researchers at Newcastle University, UK.[4]

In 2006, a second gene, on the X chromosome, was found by Italian scientists.

A third gene discovery was announced in 2007. The gene is on chromosome 10 and was also discovered by the research team in Philadelphia. The latter two genes seem to correlate with a milder form of the syndrome.
Evidence of a linkage at chromosome 3q26.3 is mixed.[5]
History

The first ever documented case was in 1916 by W. Brachmann[6] followed up by Cornelia de Lange,[7] a Dutch pediatrician, in 1933 after whom the disorder has been named.[8]
[edit] Diagnosis

The diagnosis of CdLS is primarily a clinical one based on signs and symptoms (see below) observed through an evaluation by a physician, including a medical history, physical examination, and laboratory tests. Since 2006, testing for NIPBL and SMC1A has been available through the University of Chicago [1]. This is best accomplished through a referral to a genetics specialist or clinic.
CdLS is thought to be underdiagnosed and frequently misdiagnosed.[citation needed]

Features and characteristics
Following are the features and characteristics which help in spotting this disorder:

• Low birth weight (usually under 5 pounds / 2.5 kilograms)
• Delayed growth and small stature
• Developmental delay
• Limb differences (missing limbs or portions of limbs)
• Small head size (microcephaly)
• Thick eyebrows, which typically meet at midline (synophrys)
• Long eyelashes
• Short upturned nose and thin downturned lips
• Long philtrum
• Excessive body hair
• Small hands and feet
• Small widely spaced teeth
• Low-set ears
• Hearing impairments
• Vision abnormalities (e.g., ptosis, nystagmus, high myopia, hypertropia)
• Partial joining of the second and third toes
• Incurved 5th fingers
• Gastroesophageal reflux
• Seizures
• Heart defects
• Cleft palate
• Feeding problems

Children with this syndrome are often found to have long eyelashes, bushy eyebrows and synophrys (joined eyebrows). Body hair can be excessive and affected individuals are often shorter than their immediate family members.
CdLS can give rise to its own array of complexities. Children with CdLS often suffer from gastrointestinal tract difficulties, particularly gastroesophageal reflux. Vomiting, intermittent poor appetite, constipation, diarrhea or gaseous distention are known to be a regularity in cases where the GE tract problems are acute. However, symptoms may range from mild to severe.
CdLS may also include a number of behavior problems, including self-stimulation, aggression, self-injury or strong preference to a structured routine. Many children with CdLS exhibit autistic-like behaviors.
Behavior problems in CdLS are not inevitable. Many behavior issues associated with CdLS are reactive (i.e., something happens within the person's body or environment to bring on the behavior), and cyclical (comes and goes). Often, an underlying medical issue causes a change in behavior. Once the medical issue is treated, the behavior diminishes.

 

We did not...it went from Grammar School, to Middle School, on through High School and now we are in the third semester of College! English 205 will be the next course....English Literature, aka; CDL Handbook and it's hypocritical lessons to be learned.

 

{taking mind out of gutter to answer this }

I got nothing...

{ putting mind back in gutter }

Ohhhhh....