05' Classic with Detroit 14 liter Engine- V

Have you checked the main harness to the ecm for brittle or burnt spots? The filter running empty would suggest the fuel pumps not working, but if the ecm is not communicating, that could possibly explain it. I’d start with the least expensive possibility, and work my way up. There about a half zillion wires in that harness, and it only takes one to short, and burn thru, or get brittle, and break. Good luck to ya brother.

 

@swaan may be able to help.

 

I think he answered his own question.

The filter shouldn't be dry. Sounds like you've lost prime. Its Sucking air somewhere.

 

those trucks are known for the fuel lines collapsing inside of the braided metal line. check that cross over line also