There's a study on Vehicle Response to Aerodynamic Loads (1988), along with others in a related topic here. Also, there's a Review of Aerodynamic Drag Reduction Devices for Heavy Trucks and Buses, which includes a section on Management of airflow around the tractor-trailer gap.
I love the tough guys who feel the need to run *right on* the ###### zipper. Maybe I'm a chicken, but when I'm on the bike I try not to get anywhere near another vehicle.