Melatonin supplement linked to 90% higher heart failure

Chinatown · Nov 4, 2025 at 4:37 PM

Melatonin supplement linked to 90% higher heart failure risk in new study

Tb0n3 · Nov 4, 2025 at 4:50 PM

Here's a more honest title from heart.org.
Long-term use of melatonin supplements to support sleep may have negative health effects
Preliminary study not peer reviewed.

The association between melatonin and increased risk of heart failure or death found in this study, which cannot prove a cause-and-effect relationship, raises safety concerns about the use of melatonin, which is widely available, and may warrant more research on melatonin to assess its cardiovascular safety, researchers said.
Note: The study featured in this news release is a research abstract. Abstracts presented at American Heart Association’s scientific meetings are not peer-reviewed, and the findings are considered preliminary until published as full manuscripts in a peer-reviewed scientific journal.
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Chinatown · Nov 4, 2025 at 4:51 PM

I take a 10 mg every night and have for at least 25 years.

Tb0n3 · Nov 4, 2025 at 4:53 PM

Chinatown said: ↑

I take a 10 mg every night and have for at least 25 years.
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That's a massive amount. Even 1mg is too much. I think the recommended dosage is something like 0.3 mg.

Iirc large doses could lead to insensitivity and further sleep problems.

Tb0n3 · Nov 4, 2025 at 4:56 PM

https://www.goodrx.com/conditions/insomnia/how-much-melatonin-is-too-much

Apparently the human body produces between 0.1mg and 0.9mg naturally per day.

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