Question about the dot physical

I can't speak for the diabetes portion of your post, but as to your size I can say this; there are guys a lot bigger than u driving trucks all over America...so long as your active and mobile I wouldn't worry about it...of course I'm no doctor.

 

350 and have diebetas? Unless your a 6ft 8 body builder
I would suggest you take seriouse action before you go
OTR. There are good medications and treatments available
to help you lose the weight. Because once you go OTR
its only going to get worse otherwise. Don't really know
what most companies think of Diebetics. I knew a guy
who was fired for not disclosing anti seizure meds.
Others can't get hired because of past back problems.
If you can beat the problem and get healthy, I would not
tell them, but not telling you to lie. Main thing is, get yourself
right before you get into a truck. I knew a guy about 350
that slipped off a loading dock and shatterd his leg. That
much weight is trouble with a new truck driver IMO
the old ones tend to know how to deal with it.

 

The only thing the regs say about diabetes is under 391.41:

Has no established medical history or clinical diagnosis of diabetes mellitus currently requiring insulin for control.

As far as weight.
There are no restrictions on weight, but as stated by others, drivers tend to gain weight on the road. Weight gain is an issue for alot of drivers due to the way of life and diet along with exercise.