If you are willing/able to stay and run in the Northeast corridor, then you will typically make more money. A prime example is Heartland, they pay a Northeast bonus for drivers who will run there. Or Rainman, he hauls cars and stays on the east coast (mostly) and has said it's possible to make a heck of a lot each week.
The roads and traffic are horrible. The nice folks who live and work North of the Mason-Dixon line are a bit harsh and pushy, probably because they're living jammed together and have to fight for every inch life has to offer. All those people living atop one another causes a lot of crime to deal with. It ain't pretty and most drivers tend to shy away from the area, thus companies are willing to ante up a bit more to those who are willing to venture to the region.
If you are a person with better than average driving skills, better than average people skills, and tons of patiences you can do okay running the NE corridors.
I gave up a Carolina to SE Texas run in exchange for a Carolina to Beantown turn around. It is a lot less miles and the pay is about the same. I see Hartford, da' Bronx, the Jersey pike, and reload weekly in Philadelphia. There are about half a dozen different ways to run the trip, too. I never get bored.
Most Yankee food sux and is expensive, but I pack my own so it's not an issue. I also try not to spend money in NJ, NY, CT, and MA because of their Anti-Trucker, no idleing laws. Just another personal challenge of operating in this part of the country.
2xR is beginng to miss "mudbug stew" and other Cajun delights.