If you use common sense and there’s enough room (and it’s a legal spot) U turns aren’t a big deal. Anyone that runs LTL probably does them daily with no issue. I know I do.
If you miss a turn either go to the next exit if on a decided highway or find a shopping center or something similar to turn around in. If you’re on a two lane country road keep an eye out for a farm or small warehouse that might have room. Get creative but stay safe. And always use common sense.